Bioaccessibility of contaminants from ingested soil in humans. Method development and research on the bioaccessibility of lead and benzo[a]pyrene
For risk assessment of orally ingested contaminants it is often unknown how much of the contaminant is taken up by the human body. In most human risk assessments of soil contamination, oral bio-availability of a contaminant from soil is considered equal to the bioavailability of the contaminant from the matrix as used in toxicity studies upon which risk assessment is based.
In toxicity studies typically food and liquid matrices are used. In literature it is suggested that oral bio-availability of contaminants from soil is significantly lower. As a consequence, risks may be overestimated substantially. A simple in vitro digestion model, representative for human physiology, was developed in order to investigate the effects of a soil matrix on oral bio-availability. This model allows measuring bio-accessibility of a contaminant, i.e. the fraction of the dose ingested that becomes available for absorption into the human body. The present report describes the optimisation of the in vitro digestion model.
Authors
Specifications
- Publication title
- Bioaccessibility of contaminants from ingested soil in humans. Method development and research on the bioaccessibility of lead and benzo[a]pyrene
- Publication date
- 23 November 2001
- Publication type
- Publicatie
- Publication language
- Engels
- Product number
- 90772