Human-induced pressures are known to be one of the main causes of biodiversity loss. In order to readily assess policy impacts on biodiversity, a cost-effective evaluation tool is developed, using species sensitivity scores. We demonstrate the potential effects of a selected policy option, being woody bioenergy crop production, on a wide range of species groups in Europe. Large-scale expansions of woody biofuel plantations would have a net negative effect on the species set covered in our study, with little variation among biogeographical regions, but with considerable differences among species groups. The evaluation tool enables policy makers to assess the potential impact of decisions on future biodiversity.